All entries for: Xilio Therapeutics

March 23, 2026

Xilio Therapeutics

Neutral Outlook

Waltham, MA
51-200 employees

On August 16, 2022, the Inflation Reduction Act of 2022, or the IRA, was signed into law. The new legislation has implications for Medicare Part D, which is a program available to individuals who are entitled to Medicare Part A or enrolled in Medicare Part B, to give them the option of paying a monthly premium for outpatient prescription drug coverage. Among other things, the IRA requires manufacturers of certain drugs to engage in price negotiations with Medicare (beginning in 2026), with prices that can be negotiated subject to a cap; imposes rebates under Medicare Part B and Medicare Part D to penalize price increases that outpace inflation (first due in 2023); and replaces the Part D coverage gap discount program with a new discounting program (beginning in 2025). The IRA permits the Secretary of HHS to implement many of these provisions through guidance, as opposed to regulation, for the initial years.

Disease Area: Oncology
Drug Type: Biologic
November 12, 2025

Xilio Therapeutics

Neutral Outlook

Waltham, MA
51-200 employees

Thereafter, the administration delayed the October 1, 2025 effective date of the tariffs on branded or patented pharmaceutical products announcing that the administration had now “begun preparing” tariffs on manufacturers that don’t build in the Untied States or enter into a most-favored-nation drug pricing agreement with the administration.

May 8, 2025

Xilio Therapeutics

Negative Outlook

Waltham, MA
51-200 employees

Accordingly, while it is currently unclear how the IRA will be effectuated, we cannot predict with certainty what impact any federal or state health reforms will have on us, but such changes could impose new or more stringent regulatory requirements on our activities or result in reduced reimbursement for our products, any of which could adversely affect our business, results of operations and financial condition.

Disease Area: Immune Diseases, Multiple, Oncology
Drug Type: Biologic
November 9, 2023

Xilio Therapeutics

Negative Outlook

Waltham, MA
51-200 employees
Disease Area: Oncology
Drug Type: Biologic
August 14, 2023

Xilio Therapeutics

Negative Outlook

Waltham, MA
51-200 employees
Disease Area: Oncology
Drug Type: Biologic
May 9, 2023

Xilio Therapeutics

Negative Outlook

Waltham, MA
51-200 employees
Disease Area: Oncology
Drug Type: Biologic
November 9, 2022

Xilio Therapeutics

Negative Outlook

Waltham, MA
51-200 employees

Note: Xilio described the IRA in a risk section entitled “Current and future legislative efforts may limit the prices for our products, if and when they are licensed for marketing, and that could materially impact our ability to generate revenues”

Disease Area: Oncology
Drug Type: Biologic
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