All entries for: Cardiology

June 23, 2026

Tourmaline Bio

Layoffs

New York, NY
1-50 employees

Tourmaline Bio said goodbye to 60 employees at its New York headquarters months after being swallowed by Novartis.

The workforce reduction stems from the closure of a Tourmaline site at 27 West 24th in New York, according to a Workers Adjustment and Retraining Notification (WARN) alert for the state. The layoffs took effect May 29, though the notice was only posted last week.

Novartis moved to acquire Tourmaline in September last year, putting around $1.4 billion on the line on a fully diluted basis, the pharma said at the time. The transaction closed in late October.

Novartis has conducted several rounds of layoffs this year, including one that takes effect in August and will leave 76 New Jersey workers jobless. The pharma also announced in May that it would shutter a Germany facility by the end of 2028, which will affect 220 jobs. Novartis ran two other cycles of terminations—one in March and another in April—which together affected more than 170 staff in New Jersey.

Disease Area: Cardiology, Immune Diseases, Multiple
Drug Type: Biologic
May 12, 2026

CalciMedica, Inc.

Neutral Outlook

La Jolla, California
1-50 employees

While we do not believe that the IRA or its effects will impact our ability to obtain patents in the near future, we cannot be certain whether it will affect our patent strategy in the long run.

Disease Area: Cardiology, Gastrointestinal, Immune Diseases, Respiratory Diseases
Drug Type: Small Molecule
May 11, 2026

Metagenomi Therapeutics, Inc.

Neutral Outlook

Emeryville, CA
51-200 employees

The effects of the IRA on our business and the healthcare industry in general is not yet known.

Disease Area: Cardiology, Hematology, Metabolic Diseases, Rare Diseases
Drug Type: Biologic
May 11, 2026

Liquidia Corp

Neutral Outlook

Morrisville, NC
51-200 employees

The Medicare drug price negotiation program is currently subject to legal challenges and therefore, its outcome remains uncertain. We continue to evaluate the impact of the IRA on our business, operations and financial condition.

Disease Area: Cardiology, Rare Diseases, Respiratory Diseases
Drug Type: Small Molecule
May 6, 2026

Tenaya Therapeutics, Inc.

Neutral Outlook

South San Francisco, CA
51-200 employees

While we do not believe that the IRA or its effects will impact our ability to obtain patents in the near future, we cannot be certain whether it will affect our patent strategy in the long run. The laws and regulations governing patents could change in unpredictable ways that would weaken our ability to obtain new patents or to enforce our existing patent and the patents we might obtain or license in the future.

Disease Area: Cardiology, Neurological Diseases, Rare Diseases
Drug Type: Biologic, Small Molecule
May 5, 2026

Biomarin Pharmaceuticals Inc

Neutral Outlook

San Rafael, CA
1000-5000 employees

Thus, while it is unclear how the IRA will be implemented, it will likely have a significant impact on the pharmaceutical industry.

Disease Area: Cardiology, Chronic Disease, Multiple, Rare Diseases
Drug Type: Biologic, Small Molecule
April 30, 2026

Ardelyx

Neutral Outlook

Waltham, MA
201-500 employees

While the impact of the IRA on us and the pharmaceutical industry cannot yet be fully determined, it is likely to be significant.

Disease Area: Cardiology, Chronic Disease, Gastrointestinal, Metabolic Diseases, Multiple
Drug Type: Small Molecule
March 30, 2026

Cyclerion Therapeutics, Inc

Negative Outlook

Cambridge, MA
51-200 employees

The impact of healthcare reform and other governmental and private payor initiatives, as well as the Inflation Reduction Act of 2022, may harm our business.

Disease Area: Cardiology, Neurological Diseases
Drug Type: Small Molecule
March 12, 2026

Mineralys Therapeutics, Inc.

Neutral Outlook

Radnor, PA
51-200 employees

it remains unclear how agencies will choose to implement the IRA and whether more formal rulemaking is forthcoming.

Disease Area: Cardiology, Chronic Disease
March 11, 2026

Tenaya Therapeutics, Inc.

Neutral Outlook

South San Francisco, CA
51-200 employees

While we do not believe that the IRA or its effects will impact our ability to obtain patents in the near future, we cannot be certain whether it will affect our patent strategy in the long run.

Disease Area: Cardiology, Neurological Diseases, Rare Diseases
Drug Type: Biologic, Small Molecule
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