All entries for: Chronic Disease

March 20, 2026

InflaRx N.V.

Neutral Outlook

Jena, Germany
51-200 employees

In 2022, the Inflation Reduction Act, or the IRA, was enacted, which, among other provisions, included several measures intended to lower the cost of prescription drugs and related healthcare reforms. Specifically, the IRA authorizes and directs the U.S. Department of Health and Human Services or the DHHS to set drug price caps for certain high-cost Medicare qualified drugs and the first year of maximum price applicability to begin in 2026. The IRA further authorizes the DHHS to penalize pharmaceutical manufacturers that increase the price of certain Medicare drugs faster than the rate of inflation. Finally, the IRA creates significant changes to certain Medicare benefits by capping certain beneficiaries’ annual out-of-pocket spending at $2,000 beginning in 2025.

Disease Area: Chronic Disease, Immune Diseases, Infectious Diseases
Drug Type: Biologic, Small Molecule
March 12, 2026

Mineralys Therapeutics, Inc.

Neutral Outlook

Radnor, PA
51-200 employees

it remains unclear how agencies will choose to implement the IRA and whether more formal rulemaking is forthcoming.

Disease Area: Cardiology, Chronic Disease
March 5, 2026

GSK plc

Negative Outlook

London, England
10,000+ employees

In ovarian cancer, Zejula saw a decrease in sales, driven by ongoing volume reductions, including impacts of an FDA labelling update restricting use to certain patient populations, and the impacts of IRA Medicare Part D redesign in the US

Disease Area: Antiviral, Chronic Disease, Gastrointestinal, Hematology, Immune Diseases, Infectious Diseases, Metabolic Diseases, Oncology, Respiratory Diseases
Drug Type: Biologic, Small Molecule
March 5, 2026

Altimmune, Inc

Neutral Outlook

Gaithersburg, MD
1-50 employees

The effect of IRA on our business and the healthcare industry in general is not yet known.

Disease Area: Chronic Disease, Gastrointestinal, Metabolic Diseases
Drug Type: Biologic, Small Molecule
March 5, 2026

EyePoint Inc

Negative Outlook

Watertown, MA
51-200 employees

The Inflation Reduction Act of 2022 and other changes in healthcare law may impact the prices we are able to obtain for our products and our obligations to make payments to the government.

Disease Area: Chronic Disease, Rare Diseases
Drug Type: Small Molecule
February 26, 2026

Akebia Therapeutics, Inc.

Negative Outlook

Cambridge, MA
201-500 employees

However, there are many variables that are outside of our control and if we increase the price of Auryxia or Vafseo faster than the pace of inflation, we would be subject to additional rebates under Medicare, which could have a material adverse effect on our product revenues.

Disease Area: Chronic Disease, Hematology, Multiple
Drug Type: Small Molecule
February 26, 2026

BioMarin Pharmaceutical Inc.

Neutral Outlook

San Rafael, CA
1000-5000 employees

Thus, while it is unclear how the IRA will be implemented, it will likely have a significant impact on the pharmaceutical industry.

Disease Area: Cardiology, Chronic Disease, Multiple, Rare Diseases
Drug Type: Biologic, Small Molecule
February 26, 2026

Fate Therapeutics

Negative Outlook

San Diego, CA
51-200 employees

Although the effects of the IRA on our business and the healthcare industry in general are not yet known, we are taking into consideration the potential impact of the IRA on our development and commercialization activities.

Disease Area: Chronic Disease, Immune Diseases, Oncology, Rare Diseases
Drug Type: Biologic, Small Molecule
February 26, 2026

Ionis Pharmaceutical

Neutral Outlook

Carlsbad, CA
1,001-5,000 employees

In addition, the Inflation Reduction Act of 2022, or the IRA, includes key actions aimed at reducing the costs of prescription drugs and allows HHS to negotiate the price of certain single-source drugs covered under Medicare and establish a price cap on such drugs.

Disease Area: Antiviral, Cardiology, Chronic Disease, Hematology, Metabolic Diseases, Neurological Diseases, Rare Diseases
Drug Type: Biologic
February 24, 2026

Gilead Sciences - Foster City

Negative Outlook

Foster City, CA
10,000+ employees

While the full impact of the IRA on our business and the pharmaceutical industry remains uncertain at this time, we anticipate that the IRA will increase our payment obligations under the redesigned Part D discount program, limit the prices we can charge for our products, and increase the rebates we must provide government programs for our products, thereby reducing our profitability and negatively impacting our financial results.

Disease Area: Antiviral, Chronic Disease, Multiple, Oncology
Drug Type: Biologic, Small Molecule
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