Incubate’s Investment Tracker measures the impacts of the Inflation Reduction Act’s healthcare provisions on the life sciences ecosystem, with special attention to the impacts of the small molecule penalty.

Date
Date
Disease Area
Drug Type
Announcement Type
Company Size
March 18, 2025

Pyxis Oncology

Layoffs

Boston, MA
1-50 employees

20% reduction in workforce.

Disease Area: Rare Diseases
Drug Type: Biologic, Small Molecule
March 13, 2025

Sutro Biopharma

Layoffs

South San Francisco, CA
201-500 employees

Reducing headcount by nearly 50 percent.

Disease Area: Rare Diseases
Drug Type: Biologic, Small Molecule
March 11, 2025

Kiromic Biopharma

Layoffs

Houston, TX
1-50 employees

Furloughed substantially all of its workforce.

Disease Area: Rare Diseases
Drug Type: Biologic, Small Molecule
March 6, 2025

Bristol Myers Squibb

Layoffs

Princeton, NJ
10,001-50,000 employees

Bristol Myers Squibb will lay off 57 workers from its Redwood City, California facility next month, according to a WARN notice filed on February 26. The latest layoff, first reported by Fierce Pharma, is part of a billion-plus-dollar cost-cutting program announced last year and expanded last month. BMS laid off more than two thousand employees in 2024 in total. According to BMS’ website, its Redwood City R&D campus is focused on the tumor microenvironment.

Disease Area: Multiple, Oncology
Drug Type: Biologic, Small Molecule
March 6, 2025

Atea Pharmaceuticals

Layoffs

Boston, MA
51-200 employees

25% reduction in workforce.

Disease Area: Rare Diseases
Drug Type: Biologic, Small Molecule
March 5, 2025

ALX Oncology

Layoffs

San Francisco, CA
51-200 employees

ALX Oncology, a Bay Area biotech firm currently running clinical trials for its anticancer therapy, announced Wednesday that it’s laying off about 30% of its staff.

Disease Area: Multiple, Oncology, Rare Diseases
Drug Type: Small Molecule
February 28, 2025

CRISPR Therapeutics

Layoffs

Switzerland
51-200 employees

Laying off an undisclosed number of employees.

Disease Area: Rare Diseases
Drug Type: Biologic, Small Molecule
February 25, 2025

Lava Therapeutics

Layoffs

Netherlands
51-200 employees

Laying off 30% of its staff.

Disease Area: Rare Diseases
Drug Type: Biologic, Small Molecule
February 13, 2025

Kojin Therapeutics

Discontinued Research

Boston, MA
1-50 employees

“Kojin Therapeutics will be restructuring and winding down its operations in the coming months. Since last year, with a new leadership team in place, we have made striking progress in developing first-in-class, small-molecule, ferroptosis inducers for potential use in patients with cancer and autoimmune diseases. However, obtaining sufficient funding to propel these programs forward into IND-enabling studies and clinical trials has proven difficult to achieve.”

1 Discontinued Research Program

Disease Area: Chronic Disease, Immune Diseases, Multiple, Oncology
Drug Type: Small Molecule
February 13, 2025

Encoded Therapeutics

Layoffs

South San Francisco, CA
51-200 employees

29% reduction in workforce, mostly in technology and early-stage R&D functions.

Disease Area: Rare Diseases
Drug Type: Biologic, Small Molecule
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