All entries for: Small Molecule

August 3, 2023

Vir Biotechnology

Discontinued Drug, Discontinued Research

San Francisco, CA
501-1,000 employees
501-1000 employees

“Vir Biotechnology is narrowing its focus. Sitting on $1.9 billion, the infectious disease specialist has decided to stop work on its innate immunity small-molecule platform as part of its efforts to ‘judiciously allocate’ its capital.

San Francisco-based Vir was already primarily focused on biologics, making its name through work on the anti-SARS-CoV-2 antibody Xevudy and advancing a pipeline featuring other modalities including T-cell vaccines and siRNAs. But small molecules were in the mix, too, with the biotech identifying the modality as part of its plans for a multi-respiratory hepatitis B cure and response to COVID-19…

‘We are taking measures to continuously evaluate and judiciously allocate this capital to maximize value for our shareholders,’ De Backer said. ‘As part of this process and under my leadership, we made the decision to phase out our small molecule platform. This is the first step as we continue to advance our core capabilities and scientific programs.'”

2 Discontinued Drugs: unnamed multi-respiratory hepatitis B drug (small molecule), unnamed COVID-19 drug (small molecule)
2 Discontinued Research Programs

Disease Area: Multiple
Drug Type: Small Molecule
August 3, 2023

IGM Biosciences

Negative Outlook

Mountain View, CA
201-500 employees
201-500 employees

“The implementation of cost containment measures, including the prescription drug provisions under the Inflation Reduction Act, as well as other healthcare reforms may prevent us from being able to generate revenue, attain profitability, or commercialize our product candidates if approved.”

Disease Area: Multiple, Oncology
Drug Type: Biologic, Small Molecule
August 2, 2023

Cerevel Therapeutics

Negative Outlook

Cambridge, MA
201-500 employees
201-500 employees
Disease Area: Neurological Diseases
Drug Type: Small Molecule
August 1, 2023

Exelixis

Negative Outlook

Alameda, CA
1,001-5,000 employees
1001-5000 employees
Disease Area: Oncology
Drug Type: Small Molecule
July 27, 2023

Bristol Myers Squibb

Negative Outlook

Princeton, NJ
10,001-50,000 employees
10001-50000 employees
Drug Type: Biologic, Small Molecule
July 25, 2023

Biogen

Negative Outlook

Cambridge, MA
5,001-10,000 employees
5001-10000 employees
Disease Area: Neurological Diseases
Drug Type: Biologic, Small Molecule
July 23, 2023

Alkermes

Negative Outlook

Dublin, Ireland
1,001-5,000 employees
1001-5000 employees
Disease Area: Oncology
Drug Type: Small Molecule
May 19, 2023

Novartis

Discontinued Drug, Discontinued Research

Basel, Switzerland
50,001+ employees
50001+ employees

“In an interview with Barron’s, Narasimhan said some of the programs which Novartis discontinued were cancer drugs in early-stage trials.

“We saw assets that were noncompetitive, or we thought might be unduly affected by IRA,” Narasimhan said.

The CEO said “a few” of the cancer drugs being dropped from Novartis’s pipeline were discontinued because of price negotiations.

The drugs that were dropped were “in areas where we didn’t think we could do a development plan that would allow us to successfully get the drug in patients, and fully developed across the range of indications within nine years,” Narasimhan said. They were in cancers particularly affecting the elderly, given that Medicare treats adults aged 65 and older.”

2 Discontinued Drugs: unnamed cancer drugs
2 Discontinued Research Programs

Disease Area: Oncology
Drug Type: Biologic, Small Molecule
May 12, 2023

IGM Biosciences

Negative Outlook

Mountain View, CA
201-500 employees
201-500 employees

“The implementation of cost containment measures, including the prescription drug provisions under the Inflation Reduction Act, as well as other healthcare reforms may prevent us from being able to generate revenue, attain profitability, or commercialize our product candidates if approved.”

Disease Area: Multiple, Oncology
Drug Type: Biologic, Small Molecule
May 10, 2023

Pfizer

Neutral Outlook

New York, NY
50,001+ employees
50001+ employees
Disease Area: Multiple, Oncology
Drug Type: Biologic, Small Molecule
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